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KMID : 0363619990200030018
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Journal of Korean Oriental Medicine
1999 Volume.20 No. 3 p.18 ~ p.26
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The Effect of Chungmanbunso-whoan (CBW) on Mouse Hepatocyte Damages Induced by Paraquat
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Lee Yong-Un
Kim Hee-Chul
Kim Jung-Sang
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Abstract
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This paper aims to determine the effect of CBW on the liver of mice treated with PQ (paraquat) examined by light and transmission electron microscope. Under light microscopic observations, the 2 days control showed mild congestion and necrosis of liver while those were manifest in the 7 days control. When electron microscopy was used, mitochondria and rough endoplasmic reticulum were dilated or destructed in the 2 days control and 7 days control, respectively. Under light microscopic observations, the 2 days experimental group did not show any hepatic damages while accumulation of glycogen granules in the cytoplasm was conspicuous in the 7 days experimental group. When electron microscopy was used, mitochondria and rough endoplasmic reticulum were less dilated in the 2 days experirrlental group. On the other hand, denaturation of cell organelles was not observed in the 7 days experimental group. These results suggest that CBW seems related with recovery from the PQ cytotoxity.
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KEYWORD
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CBW(Chungmanbunso-whoan), PQ(paraquat), hepatic damages
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